This paper provides an overview of the 25 th European Safety and Reliability Conference (ESREL 201 5). Through statistically categorizing the keynote speeches and technical papers,from a perspective of systems security ap-proach,popular topics in the field of safety and reliability including resilience theory,safety assessment theory and uncer-tainty theory are summarized in this paper and their applications in the field of transportation system are introduced.Fi-nally,the trend of risk prevention and control of the transportation system based on the popular topics presented at the ESREL 201 5 are illustrated and a safety assessment framework of transportation system based on the resilience theory is presented.